Functional changes in cytotoxic CD8+ T-cell cross-reactivity against the SARS-CoV-2 Omicron variant after mRNA vaccination

Functional changes in cytotoxic CD8+ T-cell cross-reactivity against the SARS-CoV-2 Omicron variant after mRNA vaccination

Understanding the T-cell responses involved in inhibiting COVID-19 severity is crucial for developing new therapeutic and vaccine strategies. Here, we characterized SARS-CoV-2 spike-specific CD8+ T cells in vaccinees longitudinally. The BNT162b2 mRNA vaccine can induce spike-specific CD8+ T cells cr...

Full description

Bibliographic Details
Main Authors: Takuto Nogimori, Koichiro Suzuki, Yuji Masuta, Ayaka Washizaki, Mika Yagoto, Mami Ikeda, Yuki Katayama, Hidenori Kanda, Minoru Takada, Shohei Minami, Takeshi Kobayashi, Shokichi Takahama, Yasuo Yoshioka, Takuya Yamamoto
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Immunology
Subjects:
COVID-19
SARS-CoV-2
mRNA vaccine
cytotoxic T cells
TCR repertoire
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1081047/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1081047/full

Similar Items