Doublecortin-Like Kinase 1 (DCLK1) Is a Novel NOTCH Pathway Signaling Regulator in Head and Neck Squamous Cell Carcinoma

Doublecortin-Like Kinase 1 (DCLK1) Is a Novel NOTCH Pathway Signaling Regulator in Head and Neck Squamous Cell Carcinoma

Despite recent advancements, the 5 year survival of head and neck squamous cell carcinoma (HNSCC) hovers at 60%. DCLK1 has been shown to regulate epithelial-to-mesenchymal transition as well as serving as a cancer stem cell marker in colon, pancreatic and renal cancer. Although it was reported that...

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Bibliographic Details
Main Authors: Esther C. Broner, Jonathan A. Trujillo, Michael Korzinkin, Tejaswini Subbannayya, Nishant Agrawal, Ivan V. Ozerov, Alex Zhavoronkov, Lisa Rooper, Nikita Kotlov, Le Shen, Alexander T. Pearson, Ari J. Rosenberg, Peter A. Savage, Vasudha Mishra, Aditi Chatterjee, David Sidransky, Evgeny Izumchenko
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Oncology
Subjects:
HNSCC
DCLK1
NOTCH
tumor microarray
transcriptomic analysis
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.677051/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2021.677051/full

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