Immunosenescence and Autoimmunity: Exploiting the T-Cell Receptor Repertoire to Investigate the Impact of Aging on Multiple Sclerosis

Immunosenescence and Autoimmunity: Exploiting the T-Cell Receptor Repertoire to Investigate the Impact of Aging on Multiple Sclerosis

T-cell receptor (TCR) repertoire diversity is a determining factor for the immune system capability in fighting infections and preventing autoimmunity. During life, the TCR repertoire diversity progressively declines as a physiological aging progress. The investigation of TCR repertoire dynamics ove...

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Bibliographic Details
Main Authors: Roberta Amoriello, Alice Mariottini, Clara Ballerini
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Immunology
Subjects:
multiple sclerosis
T cell receptor (TCR)
disease modifying therapies (DMTs)
aging
autoimmune diseases
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.799380/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.799380/full

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