Preventing BRCA1/ZBRK1 repressor complex binding to the GOT2 promoter results in accelerated aspartate biosynthesis and promotion of cell proliferation

Breast cancer susceptibility gene 1 (BRCA1) has been implicated in modulating metabolism via transcriptional regulation. However, direct metabolic targets of BRCA1 and the underlying regulatory mechanisms are still unknown. Here, we identified several metabolic genes, including the gene which encode...

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Bibliographic Details
Main Authors: Ruoxi Hong, Weimin Zhang, Xi Xia, Kai Zhang, Yan Wang, Mengjiao Wu, Jiawen Fan, Jinting Li, Wen Xia, Fei Xu, Jie Chen, Shusen Wang, Qimin Zhan
Format: Article
Language:English
Published: Wiley 2019-04-01
Series:Molecular Oncology
Subjects:
Online Access:https://doi.org/10.1002/1878-0261.12466