Upregulation of DRG protein TMEM100 facilitates dryskin-induced pruritus by enhancing TRPA1 channel function

Upregulation of DRG protein TMEM100 facilitates dryskin-induced pruritus by enhancing TRPA1 channel function

The dry skin tortures numerous patients with severe itch. The transient receptor potential cation channel V member 1 (TRPV1) and A member 1 (TRPA1) are two essential receptors for peripheral neural coding of itch sensory, mediating histaminergic and nonhistaminergic itch separately. In the dorsal ro...

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Bibliographic Details
Main Authors: Pan Chao, Jiao Yingfu, Kong Dexu, Deng Haoyue, Xu Saihong, Tang Dan, Yin Wen, Gao Po, Yu Weifeng, Fan Yinghui, Wen Daxiang
Format: Article
Language:English
Published: China Science Publishing & Media Ltd. 2022-12-01
Series:Acta Biochimica et Biophysica Sinica
Subjects:
dry skin-induced itch
TMEM100
TRPA1
TRPV1
DRG
Online Access:https://www.sciengine.com/doi/10.3724/abbs.2022180

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https://www.sciengine.com/doi/10.3724/abbs.2022180

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