Dysregulated anti-oxidant signalling and compromised mitochondrial integrity negatively influence regulatory T cell function and viability in liver diseaseResearch in context

Dysregulated anti-oxidant signalling and compromised mitochondrial integrity negatively influence regulatory T cell function and viability in liver diseaseResearch in context

Summary: Background: Dysregulated inflammatory responses and oxidative stress are key pathogenic drivers of chronic inflammatory diseases such as liver cirrhosis (LC). Regulatory T cells (Tregs) are essential to prevent excessive immune activation and maintain tissue homeostasis. While inflammatory...

Full description

Bibliographic Details
Main Authors: Trishan Vaikunthanathan, Emmanuelle Landmann, Diana Marin Correa, Marco Romano, Silvia Cellone Trevelin, Qi Peng, Elena Crespo, Mauro Corrado, Juan-José Lozano, Erika L. Pearce, Elena Perpinan, Anna Zoccarato, Leonard Siew, Joy Edwards-Hicks, Reenam Khan, Nguyet-Thin Luu, Mark R. Thursz, Philip N. Newsome, Marc Martinez-Llordella, Naina Shah, Robert I. Lechler, Ajay M. Shah, Alberto Sanchez-Fueyo, Giovanna Lombardi, Niloufar Safinia
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:EBioMedicine
Subjects:
Liver cirrhosis
Regulatory T cells
Redox homeostasis
Nrf2/heme oxygenase-1
Mitochondria
Oxidative stress
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396423003444

Internet

http://www.sciencedirect.com/science/article/pii/S2352396423003444

Similar Items