Co-Amorphous Formation of Simvastatin-Ezetimibe: Enhanced Physical Stability, Bioavailability and Cholesterol-Lowering Effects in LDLr−/−Mice

Co-Amorphous Formation of Simvastatin-Ezetimibe: Enhanced Physical Stability, Bioavailability and Cholesterol-Lowering Effects in LDLr−/−Mice

Hypercholesterolemia is one of the independent risk factors for the development of cardiovascular diseases such as atherosclerosis. The treatment of hypercholesterolemia is of great significance to reduce clinical cardiovascular events and patient mortality. Simvastatin (SIM) and ezetimibe (EZE) are...

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Bibliographic Details
Main Authors: Shamuha Bahetibieke, Sakib M. Moinuddin, Asiya Baiyisaiti, Xiaoang Liu, Jie Zhang, Guomin Liu, Qin Shi, Ankang Peng, Jun Tao, Chang Di, Ting Cai, Rong Qi
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Pharmaceutics
Subjects:
hypercholesterolemia
co-amorphous
simvastatin
ezetimibe
cholesterol-lowering drug
Online Access:https://www.mdpi.com/1999-4923/14/6/1258

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https://www.mdpi.com/1999-4923/14/6/1258

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