Deficiency of Interleukin-15 Confers Resistance to Obesity by Diminishing Inflammation and Enhancing the Thermogenic Function of Adipose Tissues.

Deficiency of Interleukin-15 Confers Resistance to Obesity by Diminishing Inflammation and Enhancing the Thermogenic Function of Adipose Tissues.

IL-15 is an inflammatory cytokine secreted by many cell types. IL-15 is also produced during physical exercise by skeletal muscle and has been reported to reduce weight gain in mice. Contrarily, our findings on IL-15 knockout (KO) mice indicate that IL-15 promotes obesity. The aim of this study is t...

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Bibliographic Details
Main Authors: Gregory Lacraz, Volatiana Rakotoarivelo, Sebastien M Labbé, Mathieu Vernier, Christophe Noll, Marian Mayhue, Jana Stankova, Adel Schwertani, Guillaume Grenier, André Carpentier, Denis Richard, Gerardo Ferbeyre, Julie Fradette, Marek Rola-Pleszczynski, Alfredo Menendez, Marie-France Langlois, Subburaj Ilangumaran, Sheela Ramanathan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5042499?pdf=render

Internet

http://europepmc.org/articles/PMC5042499?pdf=render

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