Genotype-Phenotype Associations of the CD-Associated Single Nucleotide Polymorphism within the Gene Locus Encoding Protein Tyrosine Phosphatase Non-Receptor Type 22 in Patients of the Swiss IBD Cohort.

Genotype-Phenotype Associations of the CD-Associated Single Nucleotide Polymorphism within the Gene Locus Encoding Protein Tyrosine Phosphatase Non-Receptor Type 22 in Patients of the Swiss IBD Cohort.

BACKGROUND:Protein tyrosine phosphatase non-receptor type 22 (PTPN22) plays an important role in immune cell function and intestinal homeostasis. The single nucleotide polymorphism (SNP) rs2476601 within the PTPN22 gene locus results in aberrant function of PTPN22 protein and protects from Crohn...

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Main Authors: Marianne R Spalinger, Jonas Zeitz, Luc Biedermann, Jean-Benoit Rossel, Michael C Sulz, Pascal Frei, Sylvie Scharl, Stephan R Vavricka, Michael Fried, Gerhard Rogler, Michael Scharl, Swiss IBD Cohort Study Group
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4964985?pdf=render

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http://europepmc.org/articles/PMC4964985?pdf=render

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