Benzylic C−H acylation by cooperative NHC and photoredox catalysis
Direct acylation of sp3 C−H bonds in complex organic molecules is not well established compared to that of sp2 C−H bonds. Here, the authors report the combination of N-heterocyclic carbene (NHC) and photoredox catalysis for the direct and site-selective acylation of benzylic C−H bonds.
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-22292-z |
| _version_ | 1818572916034371584 |
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| author | Qing-Yuan Meng Lena Lezius Armido Studer |
| author_facet | Qing-Yuan Meng Lena Lezius Armido Studer |
| author_sort | Qing-Yuan Meng |
| collection | DOAJ |
| description | Direct acylation of sp3 C−H bonds in complex organic molecules is not well established compared to that of sp2 C−H bonds. Here, the authors report the combination of N-heterocyclic carbene (NHC) and photoredox catalysis for the direct and site-selective acylation of benzylic C−H bonds. |
| first_indexed | 2024-12-15T00:04:02Z |
| format | Article |
| id | doaj.art-206c91186263457f895c2e04f24090e8 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-15T00:04:02Z |
| publishDate | 2021-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-206c91186263457f895c2e04f24090e82022-12-21T22:42:48ZengNature PortfolioNature Communications2041-17232021-04-011211810.1038/s41467-021-22292-zBenzylic C−H acylation by cooperative NHC and photoredox catalysisQing-Yuan Meng0Lena Lezius1Armido Studer2Organisch-Chemisches Institut, Westfälische Wilhelms-UniversitätOrganisch-Chemisches Institut, Westfälische Wilhelms-UniversitätOrganisch-Chemisches Institut, Westfälische Wilhelms-UniversitätDirect acylation of sp3 C−H bonds in complex organic molecules is not well established compared to that of sp2 C−H bonds. Here, the authors report the combination of N-heterocyclic carbene (NHC) and photoredox catalysis for the direct and site-selective acylation of benzylic C−H bonds.https://doi.org/10.1038/s41467-021-22292-z |
| spellingShingle | Qing-Yuan Meng Lena Lezius Armido Studer Benzylic C−H acylation by cooperative NHC and photoredox catalysis Nature Communications |
| title | Benzylic C−H acylation by cooperative NHC and photoredox catalysis |
| title_full | Benzylic C−H acylation by cooperative NHC and photoredox catalysis |
| title_fullStr | Benzylic C−H acylation by cooperative NHC and photoredox catalysis |
| title_full_unstemmed | Benzylic C−H acylation by cooperative NHC and photoredox catalysis |
| title_short | Benzylic C−H acylation by cooperative NHC and photoredox catalysis |
| title_sort | benzylic c h acylation by cooperative nhc and photoredox catalysis |
| url | https://doi.org/10.1038/s41467-021-22292-z |
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