mGluR5 regulates REST/NRSF signaling through N-cadherin/β-catenin complex in Huntington’s disease

mGluR5 regulates REST/NRSF signaling through N-cadherin/β-catenin complex in Huntington’s disease

Abstract Repressor element 1-silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF) is a transcription repressor and its expression is regulated by the Wnt pathway through β-catenin. Metabotropic glutamate receptor 5 (mGluR5) signaling plays a key role in controlling neuronal...

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Bibliographic Details
Main Authors: Jéssica M. de Souza, Khaled S. Abd-Elrahman, Fabiola M. Ribeiro, Stephen S. G. Ferguson
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Molecular Brain
Subjects:
Huntington’s disease
REST/NRSF
Wnt pathway
mGluR5
Src
zQ175
Online Access:http://link.springer.com/article/10.1186/s13041-020-00657-7

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http://link.springer.com/article/10.1186/s13041-020-00657-7

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