Design, Synthesis, and Acute Toxicity Assays for Novel Thymoquinone Derivative TQFL12 in Mice and the Mechanism of Resistance to Toxicity

TQFL12 is a novel derivative designed and synthesized on the basis of Thymoquinone (TQ) which is extracted from <i>Nigella sativa</i> seeds. We have demonstrated that TQFL12 was more effective in the treatment of TNBC than TQ. In order to directly reflect the acute toxicity of TQFL12 in...

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Bibliographic Details
Main Authors: Ting Li, Qi Tan, Chunli Wei, Hui Zou, Xiaoyan Liu, Zhiqiang Mei, Pengfei Zhang, Jingliang Cheng, Junjiang Fu
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Molecules
Subjects:
Online Access:https://www.mdpi.com/1420-3049/28/13/5149