Single point mutations at the S129 residue of α-synuclein and their effect on structure, aggregation, and neurotoxicity

Single point mutations at the S129 residue of α-synuclein and their effect on structure, aggregation, and neurotoxicity

Parkinson’s disease is an age-related neurological disorder, and the pathology of the disease is linked to different types of aggregates of α-synuclein or alpha-synuclein (aS), which is an intrinsically disordered protein. The C-terminal domain (residues 96–140) of the protein is highly fluctuating...

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Bibliographic Details
Main Authors: Esha Pandit, Lopamudra Das, Anoy Kumar Das, Sandip Dolui, Saumen Saha, Uttam Pal, Animesh Mondal, Joydeep Chowdhury, Subhas C. Biswas, Nakul C. Maiti
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Chemistry
Subjects:
amyloid
fibrillization
secondary structure
alpha-synuclein
neurotoxicity
Raman
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2023.1145877/full

Internet

https://www.frontiersin.org/articles/10.3389/fchem.2023.1145877/full

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