Flavonoids from Scutellaria amoena C. H. Wright alleviate mitochondrial dysfunction and regulate oxidative stress via Keap1/Nrf2/HO-1 axis in rats with high-fat diet-induced nonalcoholic steatohepatitis

Flavonoids from Scutellaria amoena C. H. Wright alleviate mitochondrial dysfunction and regulate oxidative stress via Keap1/Nrf2/HO-1 axis in rats with high-fat diet-induced nonalcoholic steatohepatitis

Background: Nonalcoholic steatohepatitis (NASH) is among the most common liver diseases in the world. Flavonoids from Scutellaria amoena (SAF) are used in the treatment of hepatopathy in China. However, the effect and mechanism against NASH remain unclear. We investigated the alleviating effect of S...

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Bibliographic Details
Main Authors: Qiong-Lian Fang, Xue Qiao, Xun-qing Yin, Yong-cheng Zeng, Cheng-hong Du, Yong-mei Xue, Xiu-juan Zhao, Chun-yan Hu, Feng Huang, Yu-ping Lin
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Scutellaria amoena
Flavonoids
NASH
Mitochondrial dysfunction
Oxidative stress
Keap1/Nrf2/HO-1 axis
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332222015499

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http://www.sciencedirect.com/science/article/pii/S0753332222015499

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