Structural and functional characterization of salmon STAT1, STAT2 and IRF9 homologs sheds light on interferon signaling in teleosts

Structural and functional characterization of salmon STAT1, STAT2 and IRF9 homologs sheds light on interferon signaling in teleosts

Mammalian IRF9 and STAT2, together with STAT1, form the ISGF3 transcription factor complex, which is critical for type I interferon (IFN)-induced signaling, while IFNγ stimulation is mediated by homodimeric STAT1 protein. Teleost fish are known to possess most JAK and STAT family members, however, d...

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Bibliographic Details
Main Authors: Mehrdad Sobhkhez, Astrid Skjesol, Ernst Thomassen, Linn Greiner Tollersrud, Dimitar B. Iliev, Baojian Sun, Børre Robertsen, Jorunn B. Jørgensen
Format: Article
Language:English
Published: Wiley 2014-01-01
Series:FEBS Open Bio
Subjects:
Atlantic salmon
STAT2
IRF9
IFN
Fish
Online Access:http://www.sciencedirect.com/science/article/pii/S2211546314000898

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http://www.sciencedirect.com/science/article/pii/S2211546314000898

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