CD44 deficiency represses neuroinflammation and rescues dopaminergic neurons in a mouse model of Parkinson’s disease

CD44 deficiency represses neuroinflammation and rescues dopaminergic neurons in a mouse model of Parkinson’s disease

CD44 is a transmembrane protein that transduces extracellular stimuli to immune response. Neuroinflammation is a causative factor in neurodegenerative diseases, such as Parkinson’s disease (PD). Owing to its role in inflammation, this study investigated whether CD44 is involved in the pathological p...

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Bibliographic Details
Main Authors: Yuejun Wang, Li Li, Yuting Wu, Shouping Zhang, Qianqian Ju, Yinuo Yang, Yan Jin, Hui Shi, Cheng Sun
Format: Article
Language:English
Published: Elsevier 2022-03-01
Series:Pharmacological Research
Subjects:
CD44
Neuroinflammation
Glial cells
TLR4
NF-κB
Parkinson’s disease
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661822000780

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http://www.sciencedirect.com/science/article/pii/S1043661822000780

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