Differential contribution of THIK-1 K+ channels and P2X7 receptors to ATP-mediated neuroinflammation by human microglia

Differential contribution of THIK-1 K+ channels and P2X7 receptors to ATP-mediated neuroinflammation by human microglia

Abstract Neuroinflammation is highly influenced by microglia, particularly through activation of the NLRP3 inflammasome and subsequent release of IL-1β. Extracellular ATP is a strong activator of NLRP3 by inducing K+ efflux as a key signaling event, suggesting that K+-permeable ion channels could ha...

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Bibliographic Details
Main Authors: Ali Rifat, Bernardino Ossola, Roland W. Bürli, Lee A. Dawson, Nicola L. Brice, Anna Rowland, Marina Lizio, Xiao Xu, Keith Page, Pawel Fidzinski, Julia Onken, Martin Holtkamp, Frank L. Heppner, Jörg R. P. Geiger, Christian Madry
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Journal of Neuroinflammation
Subjects:
Ion channels
Microglia
Neuroinflammation
Human brain
Neocortex
Purinergic signalling
Online Access:https://doi.org/10.1186/s12974-024-03042-6

Internet

https://doi.org/10.1186/s12974-024-03042-6

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