The mismatch-repair proteins MSH2 and MSH6 interact with the imprinting control regions through the ZFP57-KAP1 complex

The mismatch-repair proteins MSH2 and MSH6 interact with the imprinting control regions through the ZFP57-KAP1 complex

Abstract Background Imprinting Control Regions (ICRs) are CpG-rich sequences acquiring differential methylation in the female and male germline and maintaining it in a parental origin-specific manner in somatic cells. Despite their expected high mutation rate due to spontaneous deamination of methyl...

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Bibliographic Details
Main Authors: Basilia Acurzio, Francesco Cecere, Carlo Giaccari, Ankit Verma, Rosita Russo, Mariangela Valletta, Bruno Hay Mele, Claudia Angelini, Angela Chambery, Andrea Riccio
Format: Article
Language:English
Published: BMC 2022-08-01
Series:Epigenetics & Chromatin
Subjects:
LC–MS/MS
Chip-seq
Allele-specific analysis
CpG islands
Methyl CpG
Genomic imprinting
Online Access:https://doi.org/10.1186/s13072-022-00462-7

Internet

https://doi.org/10.1186/s13072-022-00462-7

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