Riluzole Does Not Affect Hippocampal Synaptic Plasticity and Spatial Memory, Which Are Impaired by Diazepam in Rats
We have previously demonstrated that riluzole has anxiolytic-like effects in rats, without affecting spontaneous alternation performance in the Y-maze test. However, the effects of riluzole on hippocampal synaptic plasticity were still unclear. In this study, we showed that bath application of riluz...
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| Format: | Article |
| Language: | English |
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Elsevier
2013-01-01
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| Series: | Journal of Pharmacological Sciences |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1347861319303159 |
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| author | Sachie Sasaki-Hamada Hiroaki Sacai Azusa Sugiyama Takahiro Iijima Akiyoshi Saitoh Masatoshi Inagaki Mitsuhiko Yamada Jun-Ichiro Oka |
| author_facet | Sachie Sasaki-Hamada Hiroaki Sacai Azusa Sugiyama Takahiro Iijima Akiyoshi Saitoh Masatoshi Inagaki Mitsuhiko Yamada Jun-Ichiro Oka |
| author_sort | Sachie Sasaki-Hamada |
| collection | DOAJ |
| description | We have previously demonstrated that riluzole has anxiolytic-like effects in rats, without affecting spontaneous alternation performance in the Y-maze test. However, the effects of riluzole on hippocampal synaptic plasticity were still unclear. In this study, we showed that bath application of riluzole did not impair long-term potentiation and long-term depression, whereas a benzodiazepine anxiolytic, diazepam, significantly impaired them. Furthermore, the acquisition of spatial memory in the Morris water maze test was impaired in diazepam-treated but not riluzole-treated rats. We thus provide further evidence for the potential usefulness of riluzole as an anxiolytic that does not cause amnesia. Keywords:: mood and anxiety disorder, amnesia, riluzole |
| first_indexed | 2024-12-14T16:13:56Z |
| format | Article |
| id | doaj.art-208703f545a54db8a168d1261b893813 |
| institution | Directory Open Access Journal |
| issn | 1347-8613 |
| language | English |
| last_indexed | 2024-12-14T16:13:56Z |
| publishDate | 2013-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pharmacological Sciences |
| spelling | doaj.art-208703f545a54db8a168d1261b8938132022-12-21T22:54:56ZengElsevierJournal of Pharmacological Sciences1347-86132013-01-011223232236Riluzole Does Not Affect Hippocampal Synaptic Plasticity and Spatial Memory, Which Are Impaired by Diazepam in RatsSachie Sasaki-Hamada0Hiroaki Sacai1Azusa Sugiyama2Takahiro Iijima3Akiyoshi Saitoh4Masatoshi Inagaki5Mitsuhiko Yamada6Jun-Ichiro Oka7Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, JapanLaboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, JapanLaboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan; Department of Neuropsychopharmacology, National Institute of Mental Health National Center of Neurology and Psychiatry, Tokyo 187-8553, JapanLaboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, JapanDepartment of Neuropsychopharmacology, National Institute of Mental Health National Center of Neurology and Psychiatry, Tokyo 187-8553, JapanDepartment of Neuropsychopharmacology, National Institute of Mental Health National Center of Neurology and Psychiatry, Tokyo 187-8553, JapanDepartment of Neuropsychopharmacology, National Institute of Mental Health National Center of Neurology and Psychiatry, Tokyo 187-8553, JapanLaboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan; Corresponding author. okaji@rs.noda.tus.ac.jpWe have previously demonstrated that riluzole has anxiolytic-like effects in rats, without affecting spontaneous alternation performance in the Y-maze test. However, the effects of riluzole on hippocampal synaptic plasticity were still unclear. In this study, we showed that bath application of riluzole did not impair long-term potentiation and long-term depression, whereas a benzodiazepine anxiolytic, diazepam, significantly impaired them. Furthermore, the acquisition of spatial memory in the Morris water maze test was impaired in diazepam-treated but not riluzole-treated rats. We thus provide further evidence for the potential usefulness of riluzole as an anxiolytic that does not cause amnesia. Keywords:: mood and anxiety disorder, amnesia, riluzolehttp://www.sciencedirect.com/science/article/pii/S1347861319303159 |
| spellingShingle | Sachie Sasaki-Hamada Hiroaki Sacai Azusa Sugiyama Takahiro Iijima Akiyoshi Saitoh Masatoshi Inagaki Mitsuhiko Yamada Jun-Ichiro Oka Riluzole Does Not Affect Hippocampal Synaptic Plasticity and Spatial Memory, Which Are Impaired by Diazepam in Rats Journal of Pharmacological Sciences |
| title | Riluzole Does Not Affect Hippocampal Synaptic Plasticity and Spatial Memory, Which Are Impaired by Diazepam in Rats |
| title_full | Riluzole Does Not Affect Hippocampal Synaptic Plasticity and Spatial Memory, Which Are Impaired by Diazepam in Rats |
| title_fullStr | Riluzole Does Not Affect Hippocampal Synaptic Plasticity and Spatial Memory, Which Are Impaired by Diazepam in Rats |
| title_full_unstemmed | Riluzole Does Not Affect Hippocampal Synaptic Plasticity and Spatial Memory, Which Are Impaired by Diazepam in Rats |
| title_short | Riluzole Does Not Affect Hippocampal Synaptic Plasticity and Spatial Memory, Which Are Impaired by Diazepam in Rats |
| title_sort | riluzole does not affect hippocampal synaptic plasticity and spatial memory which are impaired by diazepam in rats |
| url | http://www.sciencedirect.com/science/article/pii/S1347861319303159 |
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