The C2H2-Type Transcription Factor ZfpA, Coordinately with CrzA, Affects Azole Susceptibility by Regulating the Multidrug Transporter Gene atrF in Aspergillus fumigatus

The C2H2-Type Transcription Factor ZfpA, Coordinately with CrzA, Affects Azole Susceptibility by Regulating the Multidrug Transporter Gene atrF in Aspergillus fumigatus

ABSTRACT The incidence of invasive aspergillosis caused by Aspergillus fumigatus has risen steadily over the past few decades due to the limited effective treatment options and the emergence of antifungal-resistant isolates. In clinic-isolated A. fumigatus, the azole resistance mechanism is primaril...

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Bibliographic Details
Main Authors: Yeqi Li, Mengyao Dai, Ling Lu, Yuanwei Zhang
Format: Article
Language:English
Published: American Society for Microbiology 2023-08-01
Series:Microbiology Spectrum
Subjects:
drug susceptibility
negative regulator
ABC transporter
fungal pathogen
Aspergillus fumigatus
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00325-23

Internet

https://journals.asm.org/doi/10.1128/spectrum.00325-23

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