Large-scale RNA interference screening in mammalian cells identifies novel regulators of mutant huntingtin aggregation.

Large-scale RNA interference screening in mammalian cells identifies novel regulators of mutant huntingtin aggregation.

In polyglutamine (polyQ) diseases including Huntington's disease (HD), mutant proteins containing expanded polyQ stretch form aggregates in neurons. Genetic or RNAi screenings in yeast, C. elegans or Drosophila have identified multiple genes modifying polyQ aggregation, a few of which are confi...

Full description

Bibliographic Details
Main Authors: Tomoyuki Yamanaka, Hon Kit Wong, Asako Tosaki, Peter O Bauer, Koji Wada, Masaru Kurosawa, Tomomi Shimogori, Nobutaka Hattori, Nobuyuki Nukina
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0093891&type=printable

Internet

https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0093891&type=printable

Similar Items