OVOL1 inhibits breast cancer cell invasion by enhancing the degradation of TGF-β type I receptor

OVOL1 inhibits breast cancer cell invasion by enhancing the degradation of TGF-β type I receptor

Abstract Ovo-like transcriptional repressor 1 (OVOL1) is a key mediator of epithelial lineage determination and mesenchymal–epithelial transition (MET). The cytokines transforming growth factor-β (TGF-β) and bone morphogenetic proteins (BMP) control the epithelial–mesenchymal plasticity (EMP) of can...

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Bibliographic Details
Main Authors: Chuannan Fan, Qian Wang, Gerard van der Zon, Jiang Ren, Cedrick Agaser, Roderick C. Slieker, Prasanna Vasudevan Iyengar, Hailiang Mei, Peter ten Dijke
Format: Article
Language:English
Published: Nature Publishing Group 2022-04-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-022-00944-w

Internet

https://doi.org/10.1038/s41392-022-00944-w

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