Radioresistance, DNA Damage and DNA Repair in Cells With Moderate Overexpression of RPA1

Molecular responses to genotoxic stress, such as ionizing radiation, are intricately complex and involve hundreds of genes. Whether targeted overexpression of an endogenous gene can enhance resistance to ionizing radiation remains to be explored. In the present study we take an advantage of the CRIS...

Full description

Bibliographic Details
Main Authors: Ilya O. Velegzhaninov, Elena S. Belykh, Elena E. Rasova, Yana I. Pylina, Dmitry M. Shadrin, Dmitry Yu. Klokov
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Genetics
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2020.00855/full