Obeticholic Acid Derivative, T-2054 Suppresses Osteoarthritis via Inhibiting NF-κB-Signaling Pathway

Obeticholic Acid Derivative, T-2054 Suppresses Osteoarthritis via Inhibiting NF-κB-Signaling Pathway

Osteoarthritis (OA), a degenerative joint disorder, has been reported as the most common cause of disability worldwide. The production of inflammatory cytokines is the main factor in OA. Previous studies have been reported that obeticholic acid (OCA) and OCA derivatives inhibited the release of proi...

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Bibliographic Details
Main Authors: Dandan Guo, Liming He, Yaoxin Gao, Chenxu Jin, Haizhen Lin, Li Zhang, Liting Wang, Ying Zhou, Jie Yao, Yixin Duan, Renzheng Yang, Wenwei Qiu, Wenzheng Jiang
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
T-2054
osteoarthritis
RAW 264.7 cell line
ATDC5 chondrocytes
NF-κB-signaling
Online Access:https://www.mdpi.com/1422-0067/22/8/3807

Internet

https://www.mdpi.com/1422-0067/22/8/3807

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