Engineering a niche supporting hematopoietic stem cell development using integrated single-cell transcriptomics

Engineering a niche supporting hematopoietic stem cell development using integrated single-cell transcriptomics

Here, the authors use single cell RNA-sequencing to generate an atlas of signaling interactions regulating embryonic hematopoietic stem cell (HSC) development and apply this knowledge to engineer a niche sufficient to support HSC maturation in vitro.

Bibliographic Details
Main Authors: Brandon Hadland, Barbara Varnum-Finney, Stacey Dozono, Tessa Dignum, Cynthia Nourigat-McKay, Adam M. Heck, Takashi Ishida, Dana L. Jackson, Tomer Itkin, Jason M. Butler, Shahin Rafii, Cole Trapnell, Irwin D. Bernstein
Format: Article
Language:English
Published: Nature Portfolio 2022-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-28781-z

Internet

https://doi.org/10.1038/s41467-022-28781-z

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