Triiodothyronine or Antioxidants Block the Inhibitory Effects of BDE-47 and BDE-49 on Axonal Growth in Rat Hippocampal Neuron-Glia Co-Cultures

Triiodothyronine or Antioxidants Block the Inhibitory Effects of BDE-47 and BDE-49 on Axonal Growth in Rat Hippocampal Neuron-Glia Co-Cultures

We previously demonstrated that polybrominated diphenyl ethers (PBDEs) inhibit the growth of axons in primary rat hippocampal neurons. Here, we test the hypothesis that PBDE effects on axonal morphogenesis are mediated by thyroid hormone and/or reactive oxygen species (ROS)-dependent mechanisms. Axo...

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Bibliographic Details
Main Authors: Hao Chen, Rhianna K. Carty, Adrienne C. Bautista, Keri A. Hayakawa, Pamela J. Lein
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Toxics
Subjects:
axonal growth
developmental neurotoxicity
neuronal morphogenesis
PBDE
reactive oxygen species
thyroid hormone
Online Access:https://www.mdpi.com/2305-6304/10/2/92

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https://www.mdpi.com/2305-6304/10/2/92

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