Targeting Endometrial Cancer Stem Cell Activity with Metformin Is Inhibited by Patient-Derived Adipocyte-Secreted Factors

Advanced endometrial cancer continues to have a poor prognosis, due to limited treatment options, which may be further adversely impacted by obesity. Endometrial cancer stem cells have been reported to drive metastasis, chemotherapy resistance and disease relapse, but have yet to be fully characteri...

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Bibliographic Details
Main Authors: Sarah J. Kitson, Matthew Rosser, Deborah P. Fischer, Kay M. Marshall, Robert B. Clarke, Emma J. Crosbie
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Cancers
Subjects:
Online Access:https://www.mdpi.com/2072-6694/11/5/653