Metabolically controlled histone H4K5 acylation/acetylation ratio drives BRD4 genomic distribution

Metabolically controlled histone H4K5 acylation/acetylation ratio drives BRD4 genomic distribution

Summary: In addition to acetylation, histones are modified by a series of competing longer-chain acylations. Most of these acylation marks are enriched and co-exist with acetylation on active gene regulatory elements. Their seemingly redundant functions hinder our understanding of histone acylations...

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Bibliographic Details
Main Authors: Mengqing Gao, Jin Wang, Sophie Rousseaux, Minjia Tan, Lulu Pan, Lijun Peng, Sisi Wang, Wenqian Xu, Jiayi Ren, Yuanfang Liu, Martin Spinck, Sophie Barral, Tao Wang, Florent Chuffart, Ekaterina Bourova-Flin, Denis Puthier, Sandrine Curtet, Lisa Bargier, Zhongyi Cheng, Heinz Neumann, Jian Li, Yingming Zhao, Jian-Qing Mi, Saadi Khochbin
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721008834

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http://www.sciencedirect.com/science/article/pii/S2211124721008834

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