CTLA-4 antibody-drug conjugate reveals autologous destruction of B-lymphocytes associated with regulatory T cell impairment

CTLA-4 antibody-drug conjugate reveals autologous destruction of B-lymphocytes associated with regulatory T cell impairment

Germline CTLA-4 deficiency causes severe autoimmune diseases characterized by dysregulation of Foxp3+ Tregs, hyper-activation of effector memory T cells, and variable forms autoimmune cytopenia including gradual loss of B cells. Cancer patients with severe immune-related adverse events (irAE) after...

Full description

Bibliographic Details
Main Authors: Musleh M Muthana, Xuexiang Du, Mingyue Liu, Xu Wang, Wei Wu, Chunxia Ai, Lishan Su, Pan Zheng, Yang Liu
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-12-01
Series:eLife
Subjects:
CTLA-4
Treg-depletion
B cell loss
ADC
Foxp3
Online Access:https://elifesciences.org/articles/87281

Internet

https://elifesciences.org/articles/87281

Similar Items