Virus specificity and nucleoporin requirements for MX2 activity are affected by GTPase function and capsid-CypA interactions.

Virus specificity and nucleoporin requirements for MX2 activity are affected by GTPase function and capsid-CypA interactions.

Human myxovirus resistance 2 (MX2/MXB) is an interferon-induced GTPase that inhibits human immunodeficiency virus-1 (HIV-1) infection by preventing nuclear import of the viral preintegration complex. The HIV-1 capsid (CA) is the major viral determinant for sensitivity to MX2, and complex interaction...

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Bibliographic Details
Main Authors: Bailey Layish, Ram Goli, Haley Flick, Szu-Wei Huang, Robert Z Zhang, Mamuka Kvaratskhelia, Melissa Kane
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-03-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1011830

Internet

https://doi.org/10.1371/journal.ppat.1011830

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