Binding structures of SERF1a with NT17-polyQ peptides of huntingtin exon 1 revealed by SEC-SWAXS, NMR and molecular simulation

Binding structures of SERF1a with NT17-polyQ peptides of huntingtin exon 1 revealed by SEC-SWAXS, NMR and molecular simulation

The aberrant fibrillization of huntingtin exon 1 (Httex1) characterized by an expanded polyglutamine (polyQ) tract is a defining feature of Huntington's disease, a neurodegenerative disorder. Recent investigations underscore the involvement of a small EDRK-rich factor 1a (SERF1a) in promoting H...

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Bibliographic Details
Main Authors: Tien-Chang Lin, Orion Shih, Tien-Ying Tsai, Yi-Qi Yeh, Kuei-Fen Liao, Bradley W. Mansel, Ying-Jen Shiu, Chi-Fon Chang, An-Chung Su, Yun-Ru Chen, U-Ser Jeng
Format: Article
Language:English
Published: International Union of Crystallography 2024-09-01
Series:IUCrJ
Subjects:
huntingtin exon 1
polyglutamine peptides
serf1a
sec-swaxs
nmr
molecular simulation
huntington's disease
Online Access:https://journals.iucr.org/paper?S2052252524006341

Internet

https://journals.iucr.org/paper?S2052252524006341

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