Hinokiflavone induces apoptosis, cell cycle arrest and autophagy in chronic myeloid leukemia cells through MAPK/NF-κB signaling pathway

Hinokiflavone induces apoptosis, cell cycle arrest and autophagy in chronic myeloid leukemia cells through MAPK/NF-κB signaling pathway

Abstract Background Chronic myeloid leukemia (CML) is a myeloproliferative tumor originating from hematopoietic stem cells, and resistance to tyrosine kinase inhibitors (TKI) has become a major cause of treatment failure. Alternative drug therapy is one of the important ways to overcome TKI resistan...

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Bibliographic Details
Main Authors: Xiang Qin, Xi Chen, Ling Guo, Jing Liu, You Yang, Yan Zeng, Cheng Li, Wenjun Liu, Wenzhe Ma
Format: Article
Language:English
Published: BMC 2022-04-01
Series:BMC Complementary Medicine and Therapies
Subjects:
Hinokiflavone
Chronic myeloid leukemia
MAPK
NF-κB
Apoptosis
Autophagy
Online Access:https://doi.org/10.1186/s12906-022-03580-7

Internet

https://doi.org/10.1186/s12906-022-03580-7

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