Prenatal metformin exposure in a maternal high fat diet mouse model alters the transcriptome and modifies the metabolic responses of the offspring.

Prenatal metformin exposure in a maternal high fat diet mouse model alters the transcriptome and modifies the metabolic responses of the offspring.

AIMS: Despite the wide use of metformin in metabolically challenged pregnancies, the long-term effects on the metabolism of the offspring are not known. We studied the long-term effects of prenatal metformin exposure during metabolically challenged pregnancy in mice. MATERIALS AND METHODS: Female mi...

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Bibliographic Details
Main Authors: Henriikka Salomäki, Merja Heinäniemi, Laura H Vähätalo, Liisa Ailanen, Kim Eerola, Suvi T Ruohonen, Ullamari Pesonen, Markku Koulu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4277397?pdf=render

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http://europepmc.org/articles/PMC4277397?pdf=render

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