Conditional deletion of KCC2 impairs synaptic plasticity and both spatial and nonspatial memory

Conditional deletion of KCC2 impairs synaptic plasticity and both spatial and nonspatial memory

The postsynaptic inhibition through GABAA receptors (GABAAR) relies on two mechanisms, a shunting effect due to an increase in the postsynaptic membrane conductance and, in mature neurons, a hyperpolarization effect due to an entry of chloride into postsynaptic neurons. The second effect requires th...

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Bibliographic Details
Main Authors: Anna Kreis, Farah Issa, Xavier Yerna, Caren Jabbour, Olivier Schakman, Marie de Clippele, Nicolas Tajeddine, Nathalie Pierrot, Jean-Noël Octave, Roberta Gualdani, Philippe Gailly
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Molecular Neuroscience
Subjects:
GABA signaling
hippocampus
memory
chloride transporters
long term potentiation
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2023.1081657/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2023.1081657/full

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