An engineered HIV-1 Gag-based VLP displaying high antigen density induces strong antibody-dependent functional immune responses
Abstract Antigen display on the surface of Virus-Like Particles (VLPs) improves immunogenicity compared to soluble proteins. We hypothesised that immune responses can be further improved by increasing the antigen density on the surface of VLPs. In this work, we report an HIV-1 Gag-based VLP platform...
Main Authors: | , , , , , , , , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2023-04-01
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Series: | npj Vaccines |
Online Access: | https://doi.org/10.1038/s41541-023-00648-4 |