Replacing murine insulin 1 with human insulin protects NOD mice from diabetes.

Replacing murine insulin 1 with human insulin protects NOD mice from diabetes.

Type 1, or autoimmune, diabetes is caused by the T-cell mediated destruction of the insulin-producing pancreatic beta cells. Non-obese diabetic (NOD) mice spontaneously develop autoimmune diabetes akin to human type 1 diabetes. For this reason, the NOD mouse has been the preeminent murine model for...

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Bibliographic Details
Main Authors: Colleen M Elso, Nicholas A Scott, Lina Mariana, Emma I Masterman, Andrew P R Sutherland, Helen E Thomas, Stuart I Mannering
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0225021

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https://doi.org/10.1371/journal.pone.0225021

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