Retroactive modulation of spike timing-dependent plasticity by dopamine

Most reinforcement learning models assume that the reward signal arrives after the activity that led to the reward, placing constraints on the possible underlying cellular mechanisms. Here we show that dopamine, a positive reinforcement signal, can retroactively convert hippocampal timing-dependent...

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Bibliographic Details
Main Authors: Zuzanna Brzosko, Wolfram Schultz, Ole Paulsen
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-10-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/09685