<i>Caesalpinia mimosoides</i> Leaf Extract Promotes Neurite Outgrowth and Inhibits BACE1 Activity in Mutant APP-Overexpressing Neuronal Neuro2a Cells

<i>Caesalpinia mimosoides</i> Leaf Extract Promotes Neurite Outgrowth and Inhibits BACE1 Activity in Mutant APP-Overexpressing Neuronal Neuro2a Cells

Alzheimer’s disease (AD) is implicated in the imbalance of several proteins, including Amyloid-β (Aβ), amyloid precursor protein (APP), and BACE1. APP overexpression interferes with neurite outgrowth, while BACE1 plays a role in Aβ generation. Medicinal herbs with effects on neurite outgrowth stimul...

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Bibliographic Details
Main Authors: Panthakarn Rangsinth, Chatrawee Duangjan, Chanin Sillapachaiyaporn, Ciro Isidoro, Anchalee Prasansuklab, Tewin Tencomnao
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Pharmaceuticals
Subjects:
Alzheimer’s disease
neurodegenerative diseases
Neuro2a/APPSwe
neuritogenesis
amyloid precursor protein
BACE1
Online Access:https://www.mdpi.com/1424-8247/14/9/901

Internet

https://www.mdpi.com/1424-8247/14/9/901

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