Synthesis and Evaluation of Bicyclo[3.1.0]hexane-Based UDP-Galf Analogues as Inhibitors of the Mycobacterial Galactofuranosyltransferase GlfT2

UDP-galactofuranose (UDP-Galf) is the donor substrate for both bifunctional galactofuranosyltransferases, GlfT1 and GlfT2, which are involved in the biosynthesis of mycobacterial galactan. In this paper, a group of UDP-Galf mimics were synthesized via reductive amination of a bicyclo[3.1.0]hexane-ba...

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Bibliographic Details
Main Authors: Todd L. Lowary, Jing Li
Format: Article
Language:English
Published: MDPI AG 2016-08-01
Series:Molecules
Subjects:
Online Access:http://www.mdpi.com/1420-3049/21/8/1053