Meta-analysis of sub-Saharan African studies provides insights into genetic architecture of lipid traits

Meta-analysis of sub-Saharan African studies provides insights into genetic architecture of lipid traits

Genetic associations and polygenic scores for lipid traits have low transferability to African individuals. Here, the authors perform a large sub-Sarahan African lipid GWAS and find that larger datasets and better global representation in discovery GWAS help to bridge this gap.

Bibliographic Details
Main Authors: Ananyo Choudhury, Jean-Tristan Brandenburg, Tinashe Chikowore, Dhriti Sengupta, Palwende Romuald Boua, Nigel J. Crowther, Godfred Agongo, Gershim Asiki, F. Xavier Gómez-Olivé, Isaac Kisiangani, Eric Maimela, Matshane Masemola-Maphutha, Lisa K. Micklesfield, Engelbert A. Nonterah, Shane A. Norris, Hermann Sorgho, Halidou Tinto, Stephen Tollman, Sarah E. Graham, Cristen J. Willer, AWI-Gen study, H3Africa Consortium, Scott Hazelhurst, Michèle Ramsay
Format: Article
Language:English
Published: Nature Portfolio 2022-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-30098-w

Internet

https://doi.org/10.1038/s41467-022-30098-w

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