Unveiling immune checkpoint regulation: exploring the power of in vivo CRISPR screenings in cancer immunotherapy

Unveiling immune checkpoint regulation: exploring the power of in vivo CRISPR screenings in cancer immunotherapy

Immune checkpoint inhibitors (ICIs) have revolutionized cancer immunotherapy by reinvigorating antitumor immune responses, but their efficacy remains limited in most patients. To address this challenge and optimize Immune check inhibitor treatment, understanding the underlying molecular intricacies...

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Bibliographic Details
Main Authors: Yuxiang Wang, Athar Khalil, Amina Kamar, Mengyan Du, Trang Dinh, Christopher McFarland, Zhenghe Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-12-01
Series:Frontiers in Genetics
Subjects:
CRISPR (clustered regularly interspaced short palindromic repeat)/Cas9 (CRISPR associated protein 9)-mediated genome editing
PD-1
immune check inhibitor (ICI)
CTLA-4
in vivo CRISPR screen
invitro CRISPR screen
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2023.1304425/full

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https://www.frontiersin.org/articles/10.3389/fgene.2023.1304425/full

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