An Algorithm for Generating Small RNAs Capable of Epigenetically Modulating Transcriptional Gene Silencing and Activation in Human Cells

An Algorithm for Generating Small RNAs Capable of Epigenetically Modulating Transcriptional Gene Silencing and Activation in Human Cells

Small noncoding antisense RNAs (sasRNAs) guide epigenetic silencing complexes to target loci in human cells and modulate gene transcription. When these targeted loci are situated within a promoter, long-term, stable epigenetic silencing of transcription can occur. Recent studies suggest that there e...

Full description

Bibliographic Details
Main Authors: Amanda Ackley, Alexandra Lenox, Kenneth Stapleton, Stuart Knowling, Tim Lu, Kenny S Sabir, Peter K Vogt, Kevin V Morris
Format: Article
Language:English
Published: Elsevier 2013-01-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
epigenetic
non-coding RNA
oncogene
transcription
tumor suppressor gene
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253116301652

Internet

http://www.sciencedirect.com/science/article/pii/S2162253116301652

Similar Items