Rabphilin-3A as a novel target to reverse α-synuclein-induced synaptic loss in Parkinson’s disease

Rabphilin-3A as a novel target to reverse α-synuclein-induced synaptic loss in Parkinson’s disease

Toxic aggregates of α-synuclein (αsyn) are considered key drivers of Parkinson’s disease (PD) pathology. In early PD, αsyn induces synaptic dysfunction also modulating the glutamatergic neurotransmission. However, a more detailed understanding of the molecular mechanisms underlying αsyn-triggered sy...

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Bibliographic Details
Main Authors: Elena Ferrari, Diego Scheggia, Elisa Zianni, Maria Italia, Marta Brumana, Luca Palazzolo, Chiara Parravicini, Andrea Pilotto, Alessandro Padovani, Elena Marcello, Ivano Eberini, Paolo Calabresi, Monica Diluca, Fabrizio Gardoni
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Pharmacological Research
Subjects:
α-synuclein
Dendritic spines
Parkinson’s disease
Protein-protein interactions
Rabphilin-3A
Mice
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661822003206

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http://www.sciencedirect.com/science/article/pii/S1043661822003206

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