Connexin 43 Deficiency Is Associated with Reduced Myocardial Scar Size and Attenuated TGFβ1 Signaling after Transient Coronary Occlusion in Conditional Knock-Out Mice

Connexin 43 Deficiency Is Associated with Reduced Myocardial Scar Size and Attenuated TGFβ1 Signaling after Transient Coronary Occlusion in Conditional Knock-Out Mice

Previous studies demonstrated a reduction in myocardial scar size in heterozygous Cx43<sup>+/-</sup> mice subjected to permanent coronary occlusion. However, patients presenting with ST segment elevation myocardial infarction often undergo rapid coronary revascularization leading to prom...

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Bibliographic Details
Main Authors: Laura Valls-Lacalle, Marta Consegal, Marisol Ruiz-Meana, Begoña Benito, Javier Inserte, Ignasi Barba, Ignacio Ferreira-González, Antonio Rodríguez-Sinovas
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Biomolecules
Subjects:
connexin 43
left ventricular remodeling
collagen
ischemia–reperfusion
myocardial infarct
Online Access:https://www.mdpi.com/2218-273X/10/4/651

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https://www.mdpi.com/2218-273X/10/4/651

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