One is not enough: On the effects of reference genome for the mapping and subsequent analyses of short-reads.
Mapping of high-throughput sequencing (HTS) reads to a single arbitrary reference genome is a frequently used approach in microbial genomics. However, the choice of a reference may represent a source of errors that may affect subsequent analyses such as the detection of single nucleotide polymorphis...
| Main Authors: | , , , , , , , |
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| 格式: | Article |
| 語言: | English |
| 出版: |
Public Library of Science (PLoS)
2021-01-01
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| 叢編: | PLoS Computational Biology |
| 在線閱讀: | https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008678&type=printable |