The Combination of Natural Molecules Naringenin, Hesperetin, Curcumin, Polydatin and Quercetin Synergistically Decreases SEMA3E Expression Levels and DPPIV Activity in In Vitro Models of Insulin Resistance

The Combination of Natural Molecules Naringenin, Hesperetin, Curcumin, Polydatin and Quercetin Synergistically Decreases SEMA3E Expression Levels and DPPIV Activity in In Vitro Models of Insulin Resistance

Type 2 diabetes mellitus (T2DM) is a disease characterized by a prolonged hyperglycemic condition caused by insulin resistance mechanisms in muscle and liver, reduced insulin production by pancreatic β cells, and a chronic inflammatory state with increased levels of the pro-inflammatory marker semap...

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Bibliographic Details
Main Authors: Emanuele-Salvatore Scarpa, Chiara Giordani, Antonella Antonelli, Massimiliano Petrelli, Giancarlo Balercia, Francesca Silvetti, Alessio Pieroni, Jacopo Sabbatinelli, Maria Rita Rippo, Fabiola Olivieri, Giulia Matacchione
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:International Journal of Molecular Sciences
Subjects:
natural molecules
insulin resistance
INSR
SEMA3E
caspase 1
DPPIV
Online Access:https://www.mdpi.com/1422-0067/24/9/8071

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https://www.mdpi.com/1422-0067/24/9/8071

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