Enhanced protective immunity against SARS-CoV-2 elicited by a VSV vector expressing a chimeric spike protein

Enhanced protective immunity against SARS-CoV-2 elicited by a VSV vector expressing a chimeric spike protein

Abstract SARS-CoV-2 and SARS-CoV are genetically related coronavirus and share the same cellular receptor ACE2. By replacing the VSV glycoprotein with the spikes (S) of SARS-CoV-2 and SARS-CoV, we generated two replication-competent recombinant viruses, rVSV-SARS-CoV-2 and rVSV-SARS-CoV. Using wild-...

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Bibliographic Details
Main Authors: Hongyue Li, Yuhang Zhang, Dong Li, Yong-Qiang Deng, Hongde Xu, Chaoyue Zhao, Jiandong Liu, Dan Wen, Jianguo Zhao, Yongchun Li, Yong Wu, Shujun Liu, Jiankai Liu, Junfeng Hao, Fei Yuan, Shuguang Duo, Cheng-Feng Qin, Aihua Zheng
Format: Article
Language:English
Published: Nature Publishing Group 2021-11-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-021-00797-9

Internet

https://doi.org/10.1038/s41392-021-00797-9

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