Sodium-glucose cotransporter 2 inhibition and health benefits: The Robin Hood effect
This review discusses two distinct, yet related, mechanisms of sodium-glucose cotransporter 2 (SGLT2) inhibition: Calorie restriction mimicry (CRM) and pro-ketogenic effect, which may explain their cardiovascular benefits. We term these adaptive CRM and pro-ketogenic effects of SGLT2 inhibition, the...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2016-01-01
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| Series: | Indian Journal of Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://www.ijem.in/article.asp?issn=2230-8210;year=2016;volume=20;issue=5;spage=725;epage=729;aulast=Kalra |
| _version_ | 1811253922539503616 |
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| author | Sanjay Kalra Arpit Jain Jignesh Ved A G Unnikrishnan |
| author_facet | Sanjay Kalra Arpit Jain Jignesh Ved A G Unnikrishnan |
| author_sort | Sanjay Kalra |
| collection | DOAJ |
| description | This review discusses two distinct, yet related, mechanisms of sodium-glucose cotransporter 2 (SGLT2) inhibition: Calorie restriction mimicry (CRM) and pro-ketogenic effect, which may explain their cardiovascular benefits. We term these adaptive CRM and pro-ketogenic effects of SGLT2 inhibition, the Robin Hood hypothesis. In English history, Robin Hood was a "good person," who stole from the rich and helped the poor. He supported redistribution of resources as he deemed fit for the common good. In a similar fashion, SGLT2 inhibition provides respite to the overloaded glucose metabolism while utilizing lipid stores for energy production. |
| first_indexed | 2024-04-12T16:59:26Z |
| format | Article |
| id | doaj.art-20cf1f136578409c857ce20c89b6da5a |
| institution | Directory Open Access Journal |
| issn | 2230-8210 |
| language | English |
| last_indexed | 2024-04-12T16:59:26Z |
| publishDate | 2016-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Endocrinology and Metabolism |
| spelling | doaj.art-20cf1f136578409c857ce20c89b6da5a2022-12-22T03:24:07ZengWolters Kluwer Medknow PublicationsIndian Journal of Endocrinology and Metabolism2230-82102016-01-0120572572910.4103/2230-8210.183826Sodium-glucose cotransporter 2 inhibition and health benefits: The Robin Hood effectSanjay KalraArpit JainJignesh VedA G UnnikrishnanThis review discusses two distinct, yet related, mechanisms of sodium-glucose cotransporter 2 (SGLT2) inhibition: Calorie restriction mimicry (CRM) and pro-ketogenic effect, which may explain their cardiovascular benefits. We term these adaptive CRM and pro-ketogenic effects of SGLT2 inhibition, the Robin Hood hypothesis. In English history, Robin Hood was a "good person," who stole from the rich and helped the poor. He supported redistribution of resources as he deemed fit for the common good. In a similar fashion, SGLT2 inhibition provides respite to the overloaded glucose metabolism while utilizing lipid stores for energy production.http://www.ijem.in/article.asp?issn=2230-8210;year=2016;volume=20;issue=5;spage=725;epage=729;aulast=KalraCalorie restriction mimicry canagliflozincardiovascular outcomesdapagliflozindiabetesEMPA-REG outcomeempagliflozinketogenesisketogenic dietliraglutide |
| spellingShingle | Sanjay Kalra Arpit Jain Jignesh Ved A G Unnikrishnan Sodium-glucose cotransporter 2 inhibition and health benefits: The Robin Hood effect Indian Journal of Endocrinology and Metabolism Calorie restriction mimicry canagliflozin cardiovascular outcomes dapagliflozin diabetes EMPA-REG outcome empagliflozin ketogenesis ketogenic diet liraglutide |
| title | Sodium-glucose cotransporter 2 inhibition and health benefits: The Robin Hood effect |
| title_full | Sodium-glucose cotransporter 2 inhibition and health benefits: The Robin Hood effect |
| title_fullStr | Sodium-glucose cotransporter 2 inhibition and health benefits: The Robin Hood effect |
| title_full_unstemmed | Sodium-glucose cotransporter 2 inhibition and health benefits: The Robin Hood effect |
| title_short | Sodium-glucose cotransporter 2 inhibition and health benefits: The Robin Hood effect |
| title_sort | sodium glucose cotransporter 2 inhibition and health benefits the robin hood effect |
| topic | Calorie restriction mimicry canagliflozin cardiovascular outcomes dapagliflozin diabetes EMPA-REG outcome empagliflozin ketogenesis ketogenic diet liraglutide |
| url | http://www.ijem.in/article.asp?issn=2230-8210;year=2016;volume=20;issue=5;spage=725;epage=729;aulast=Kalra |
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