Beyond PD(L)-1 Blockade in Microsatellite-Instable Cancers: Current Landscape of Immune Co-Inhibitory Receptor Targeting

Beyond PD(L)-1 Blockade in Microsatellite-Instable Cancers: Current Landscape of Immune Co-Inhibitory Receptor Targeting

High microsatellite instability (MSI-H) derives from genomic hypermutability due to deficient mismatch repair function. Colorectal (CRC) and endometrial cancers (EC) are the tumor types that more often present MSI-H. Anti-PD(L)-1 antibodies have been demonstrated to be agnostically effective in pati...

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Bibliographic Details
Main Authors: Edoardo Crimini, Luca Boscolo Bielo, Pier Paolo Maria Berton Giachetti, Gloria Pellizzari, Gabriele Antonarelli, Beatrice Taurelli Salimbeni, Matteo Repetto, Carmen Belli, Giuseppe Curigliano
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Cancers
Subjects:
cancer
microsatellite instability
immunotherapy
PD-L1
precision oncology
drug development
Online Access:https://www.mdpi.com/2072-6694/16/2/281

Internet

https://www.mdpi.com/2072-6694/16/2/281

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