Changes in the Transcriptome and Chromatin Landscape in BRAFi-Resistant Melanoma Cells

Metastatic and drug-resistant melanoma are leading causes of skin cancer–associated death. Mitogen-associated protein kinase (MAPK) pathway inhibitors and immunotherapies have provided substantial benefits to patients with melanoma. However, long-term therapeutic efficacy has been limited due to eme...

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Bibliographic Details
Main Authors: Kiran Kumar Reddi, Praveen Guruvaiah, Yvonne J. K. Edwards, Romi Gupta
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Oncology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.937831/full